How to prevent and reduce disability among children, teenagers and young adults in the Paris region?

The goal of the research work presented in this "Major questions of interest" is to shed light on our understanding of the contributing factors of young people's disability situations.
 
The research program is structured around two areas.
 

The first focuses on identifying and assessing the factors that contribute to the harmonious development of children, adolescents and young adults, or to disability, and the modifiable prevention factors (primary, secondary and tertiary) involved in disability. This is based on research using innovative technologies and therapies (e.g. surgical) and on the modeling-exploitation of varied databases (longitudinal socio-epidemiological cohorts, experimental clinical cohorts, and medico-administrative data for example).

The second involves the construction and/or evaluation of innovative systems or actions in the fields of childhood and disability for children - teenagers - young adults, aimed at preventing or reducing disability situations, and proposing operational tools at local level. This area includes the transfer of scientific knowledge to society, using implementation science approaches.

 
In these two areas, links will be sought between disability situations and the following fields:

• Care pathways (needs for improvement in the field of motor and cognitive disabilities)

• Maternity-child and child-adult transition (coordination of multiple and "jump" care)

• Inclusion from school to vocational training and the job market

The scientific proposal therefore includes a diversity of approaches and partners to provide information on current issues of importance to the Ile-de-France region in terms of disability prevention, diagnosis and support. The academic and research establishments selected, as well as their respective partners, are also varied, aiming for a good representation of the players in the Ile-de-France region.
 
The nine research projects selected in the scientific proposal and their promoters:

1. Caring for the spinal cord in utero: improving the prognosis of children with myelomeningocele.
   Project sponsor: Dr Lucie Guilbaud (Sorbonne University, APHP - Fetal Medicine Department - Trousseau Hospital)

2. Multimodal study of neonatal brachial plexus paralysis.
   Project sponsor: Dr Manon Bachy-Razzouk (Sorbonne Université, AP-HP - Service de Chirurgie Orthopédique et Réparatrice de l'Enfant - Hôpital Trousseau)

3. Pre- and post-operative evaluation and management of children with central neurological lesions by selective dorsal rhizotomy.
   Project sponsor: Dr Pauline Lallemant-Dudek (Brain Institute, APHP - Pediatric Physical and Rehabilitation Medicine Department - Trousseau Hospital)

4. Disability and social-cognitive processes: study of the development of social cognition and its disorders in neurodevelopmental pathologies.
   Project sponsor: Dr. Lisa Ouss (University of Paris, APHP - Department of Child Psychiatry and Neuropediatrics - Hôpital Necker)

5. Taking genetic factors into account to understand the causes of learning disorders and identify levers to reduce them
   Project leader: Franck Ramus (DR) (Ecole Normale Supérieure (Paris) - Laboratoire de sciences cognitives et psycholinguistique UMR 8554 & CNRS)

6. A better understanding of the health and medico-social needs of young head injury victims in the Paris region, and recommendations.
   Project sponsor: Pr Eléonore Bayen (Sorbonne University, APHP - Physical and Rehabilitation Medicine Department, Hôpital Pitié-Salpêtrière)

7. Multimodal assessment of the risk of spinal cord injury during correction of complex spinal deformities: Contribution of intraoperative SWE elastography.
   Project sponsor: Dr Elie Saghbiny (Sorbonne University, AP-HP - Department of Orthopedic and Reparative Surgery for Children - Trousseau Hospital)

8. Modifiable childhood determinants of cognitive disability in adulthood.
   Project sponsor: Dr Laurent Cléret de Langavant (Université Paris-Est Créteil, APHP - Neurology Department - Hôpital Henri-Mondor)

9. Study of the long-term prognosis of nitrous oxide (N2O)-induced neurotoxicity.
   Project sponsor: Dr Thierry Gendre (Université Paris-Est Créteil, APHP - Service de Neurologie - Hôpital Henri-Mondor)