Maison des Modélisations, Ingénieries et Technologies

• Article dans une revue

Definition of a concentration and RNA extraction protocol for optimal whole genome sequencing of SARS-CoV-2 in wastewater (ANRS0160)

Ahlam Chaqroun, Ghina El Soufi, Zuzana Gerber, Julie Loutreul, Nicolas Cluzel, Damien Delafoy, Florian Sandron, Léo Di Jorio, Stéphanie Raffestin, Vincent Maréchal, Christophe Gantzer, Robert Olaso, Jean-François Deleuze, Olivier Rohr, Nicolas Boudaud, Clémentine Wallet, Isabelle Paule Bertrand

Monitoring the presence of RNA from emerging pathogenic viruses, such as SARS-CoV-2, in wastewater (WW) samples requires suitable methods to ensure an effective response. Genome sequencing of WW is one of the crucial methods, but it requires high-quality RNA in sufficient quantities, especially for…

Science of the Total Environment, 2024, 952, pp.175823. ⟨10.1016/j.scitotenv.2024.175823⟩. ⟨hal-04764746⟩

• Article dans une revue

Highly efficient and sensitive membrane-based concentration process allows quantification, surveillance, and sequencing of viruses in large volumes of wastewater

G El Soufi, L Di Jorio, Z Gerber, N Cluzel, J van Assche, D Delafoy, R Olaso, C Daviaud, T Loustau, C Schwartz, D Trebouet, O Hernalsteens, V Marechal, S Raffestin, Dominique Rousset, C van Lint, J F Deleuze, M Boni, O Rohr, M Villain-Gambier, C Wallet

Wastewater-based epidemiology is experiencing exponential development. Despite undeniable advantages compared to patient-centered approaches (cost, anonymity, survey of large populations without bias, detection of asymptomatic infected peoples…), major technical limitations persist. Among them is…

Water Research, 2024, 249, pp.120959. ⟨10.1016/j.watres.2023.120959⟩. ⟨hal-04637340⟩

• Chapitre d'ouvrage

Implementation of a National Wastewater Surveillance System in France as a Tool to Support Public Authorities During the Covid Crisis: The Obepine Project

M. Boni, S. Wurtzer, J. M. Mouchel, Y. Maday, Soizick Le Guyader, Pascal Garry, I. Bertrand, N. Cluzel, M. Courbariaux, S. Wang, C. Gantzer, V. Maréchal, L. Moulin

The Obépine project (OBservatoire EPIdémiologique daNs les Eaux usées) has brought together research teams with a variety of skills (virology, mathematics, hydrology, infectiology) to evaluate the relevance of a quantification for SARS-CoV-2 genomes and its variants in wastewater, to provide a new…

Manish Kumar, Keisuke Kuroda, Santanu Mukherjee, Long D. Ngiehm, Meththika Vithanage, and Vinay Kumar Tyagi (eds.) 2023 Wastewater Surveillance for Covid-19 Management. Part of The Handbook of Environmental Chemistry. 2023. Damià Barceló, Andrey G. Kostianoy (Eds.). Springer, Berlin, Heidelberg. https://doi.org/10.1007/698_2023_994. 29p., 2023, ⟨10.1007/698_2023_994⟩. ⟨hal-04309756⟩

• Article dans une revue

A Sparse Mixture-of-Experts Model With Screening of Genetic Associations to Guide Disease Subtyping

Marie Courbariaux, Kylliann De Santiago, Cyril Dalmasso, Fabrice Danjou, Samir Bekadar, Jean-Christophe Corvol, Maria Martinez, Marie Szafranski, Christophe Ambroise

Frontiers in Genetics, 2022, Statistical Methods, Computing, and Resources for Genome-Wide Association Studies, Volume II, 13, ⟨10.3389/fgene.2022.859462⟩. ⟨hal-01822237v5⟩