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Biologie Cellulaire et Cancer

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  • Article dans une revue

DeepCristae, a CNN for the restoration of mitochondria cristae in live microscopy images

Salomé Papereux, Ludovic Leconte, Cesar Augusto Valades-Cruz, Tianyan Liu, Julien Dumont, Zhixing Chen, Jean Salamero, Charles Kervrann, Anaïs Badoual

Mitochondria play an essential role in the life cycle of eukaryotic cells. However, we still don't know how their ultrastructure, like the cristae of the inner membrane, dynamically evolves to regulate these fundamental functions, in response to external conditions or during interaction with…

Communications Biology, In press, ⟨10.1101/2023.07.05.547594⟩. ⟨hal-04295317v1⟩

  • Article dans une revue

Basal/squamous and Mixed subtype bladder cancers present poor outcomes after neoadjuvant chemotherapy in the VESPER trial

C.S. Groeneveld, C. Pfister, S. Culine, V. Harter, C. Krucker, J. Fontugne, V. Dixon, N. Sirab, I. Bernard-Pierrot, A. de Reyniès, F. Radvanyi, Y. Allory, G. Pignot, J.P. Fendler, L. Guy, G. Verhoest, N. Mottet, A. Doerfler, S. Abadie-Lacourtoisie, A. Azzouzi, P. Mongiat, L. Geoffrois, P. Eschwege, F. Di Fiore, G. Roubaud, J.L. Hoepffner, P. Barthelemy, H. Lang, E. Voog, E. Mandron, J.M. Tourani, C. Serrrate, A. Colau, C. Saldana, A. de La Taille, T. Nguyen, F. Kleinclauss, Y. Loriot, J. Irani, J.C. Eymard, S. Larre, O. Huillard, M. Zerbib, F. Rolland, J. Rigaud, N. Houede, S. Droupy, G. Malouf, M. Roupret, S. Vieillot, N. Letang, T. Lharidon, N. Gaschignard, W. Hilgers, J.L. Davin

Background - Neoadjuvant chemotherapy (NAC) is the standard treatment for muscle-invasive bladder cancer (MIBC), yet 40% of patients progress, emphasizing the need for biomarkers predictive for response or chemoresistance. Gene expression-based subtypes may serve as biomarkers, though which…

Annals of Oncology, 2025, 36 (1), pp.89-98. ⟨10.1016/j.annonc.2024.09.008⟩. ⟨hal-04780573⟩

  • Article dans une revue

Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

Donia Zaidi, Kaviya Chinnappa, Berfu Nur Yigit, Valeria Viola, Carmen Cifuentes-Diaz, Ammar Jabali, Ana Uzquiano, Emilie Lemesre, Franck Perez, Julia Ladewig, Julien Ferent, Nurhan Ozlu, Fiona Francis

Mechanisms leading to abnormal distribution of neural progenitors during cortical development in the context of subcortical heterotopia associated with EML1 mutations remain unknown. Using a forebrain-specific mouse model and mutant human cells, this work innovatively demonstrates that by restoring…

Journal of Cell Biology, 2024, 223 (12), ⟨10.1083/jcb.202310157⟩. ⟨hal-04721394⟩

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Biologie Cellulaire et Cancer, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
Adresse physique
Biologie Cellulaire et Cancer
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05 France
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