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Biologie Cellulaire et Cancer

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  • Article dans une revue

Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

Donia Zaidi, Kaviya Chinnappa, Berfu Nur Yigit, Valeria Viola, Carmen Cifuentes-Diaz, Ammar Jabali, Ana Uzquiano, Emilie Lemesre, Franck Perez, Julia Ladewig, Julien Ferent, Nurhan Ozlu, Fiona Francis

Mechanisms leading to abnormal distribution of neural progenitors during cortical development in the context of subcortical heterotopia associated with EML1 mutations remain unknown. Using a forebrain-specific mouse model and mutant human cells, this work innovatively demonstrates that by restoring…

Journal of Cell Biology, 2024, 223 (12), ⟨10.1083/jcb.202310157⟩. ⟨hal-04721394⟩

  • Article dans une revue

The GTPase RAB6 is required for stem cell maintenance and cell migration in the gut epithelium

Pierre Simonin, Gehenna Lobo Guerrero, Sabine Bardin, Ram Venkata Gannavarapu, Denis Krndija, Joseph Boyd, Stephanie Miserey, Danijela Matic Vignjevic, Bruno Goud

ABSTRACT Intestinal epithelial cells, which are instrumental in nutrient absorption, fluid regulation, and pathogen defense, undergo continuous proliferation and differentiation within the intestinal crypts, migrating towards the luminal surface where they are eventually shed. RAB GTPases are key…

Development (Cambridge, England), 2024, 151 (21), ⟨10.1242/dev.203038⟩. ⟨hal-04781792⟩

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Biologie Cellulaire et Cancer, Institut Curie, 26 rue d’Ulm, 75248 Paris Cedex 05 France
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Biologie Cellulaire et Cancer
Institut Curie
26 rue d’Ulm
75248 Paris Cedex 05 France
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